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    Organoid Models | 3D Cell Culture | Corning

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    Explore Organoid Model Environments

    Explore Organoid Model Environments

    Organoids are generated from both pluripotent stem cells (PSCs) and adult stem cells (ASCs). Self-renewal and differentiation of stem cells is influenced by growth factors and extracellular matrices (ECM) that provide the required scaffold to support cell attachment and growth during organoid formation. Hydrogels such as Corning Matrigel? Matrix and Corning? Collagen are popular scaffold choices to support cell expansion in organoid cultures.

    Stem cells and/or organ progenitors from normal or diseased tissue can be mixed with Matrigel matrix or Collagen to create mini-organs of the kidney, thyroid, liver, brain, lung, intestine, prostate, and pancreas. Organoids support advancements in the study of organogenesis, disease modeling, and subsequent patient-specific therapies. ?For example, the combination of genome editing using CRISPR-Cas9 and organoid cultures allows researchers to evaluate DNA repair of patient-specific mutations found in certain cancers and perform genetic screens. Hydrogels such as Collagen and Matrigel Matrix can be used as bio-inks to allow precise positioning and embedding of living cells/organoids during 3D bioprinting. ?Organoids are also being used as physiologically relevant models for the development of new therapeutic drug candidates.

    Publications

    Supporting Publications for Organoid Culture

    Supporting Publications for Organoid Culture

    Cancer Phenotypes

    Discover research on organoid cultures for the analysis of cancer phenotypes.

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    Engineering Stem Cell Organoids

    Learn more about basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be implemented.

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    Disease Modeling

    Discover research examining disease modeling in stem-cell derived 3D organoid systems.

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    Organoids and Epithelial Translational Medicine

    Learn more about the advantages of stem cell-derived organoid models over existing culture systems, as well as recent advances in epithelial tissue-specific organoids.

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    Organoids, Disease Models and 3D Printing: The Challenges and Opportunities for 3D Cell Culture

    Learn about the advantages of culturing cells in three dimensions over traditional methods and look at the exciting new developments for the technology behind 3D cell culture.

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    TESTIMONIALS

    Customer Success Stories

    Solutions

    Solutions for Organoid Models

    Applications

    Organoid Model Applications

    Organoid Model Applications

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    Support

    Scientific Support–Setting a New Industry Standard

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