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    Corning? Matrigel? Matrix for Organoids | Surfaces

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    Organoids have become increasingly popular in disease modeling and drug discovery as they resemble the composition and functionality of organs. Extracellular matrix (ECM) is an important component of the cell niche that provides biochemical cues and structural support, such as porosity and stiffness which mediates signaling for cell migration1, cell behavior and polarization2 in organoid structures.

    Corning Matrigel matrix is one of the original and most widely referenced 3D cell culture tools, and our customers have done extraordinary things with this matrix. Corning’s new Matrigel matrix for organoid culture is an optimized version of this trusted product, formulated to support organoid growth and differentiation.

    Corning Matrigel matrix for organoid culture is a convenient, ready-to-use solution that provides the consistency and reliability needed for successful organoid culture by employing the following steps:

    • Verified to support growth and differentiation of mouse and human organoid cultures including:

    –?Long-term expansion of mouse small intestinal organoids for more than 7 passages with typical organoid budding morphology and marker expression3
    – Growth and differentiation of polarized 3D organoids from primary human airway epithelial cells expressing typical markers4

    • Each lot is measured for its elastic modulus, which is indicative of matrix stiffness
    • Each lot is qualified to form stable "3D dome" structures commonly used in organoid culture
    • Demonstrated to successfully grow organoids from both healthy and diseased cell origins

    As an optimized matrix, Corning Matrigel matrix for organoid culture reduces the need for time-consuming screening, while providing the reproducibility and consistency essential for organoid research.

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    1.? Hartman CD, et al. Extracellular matrix type modulates cell migration on mechanical gradients. Experimental Cell Research, vol. 359, no. 2, pp. 361-366, 2017.
    2.? Bryant DM, et al. A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, vol. 31, no. 2, pp. 171-187, (2014).
    3.? Application note: CLS-AN-542, Culture of Mouse Intestinal Organoids in Corning? Matrigel? Matrix for Organoid Culture, K. Slater and H. Nandivada
    4. Application note: CLS-AN-534, High Throughput Gene Expression Analysis of 3D Airway Organoids, H. Sherman, N. Elliott, A. White and A. Rossi

    Application Areas

    Growth and differentiation of organoids

    Growth and differentiation of organoids

    Organoids support advancements in the study of organogenesis, disease modeling, and subsequently patient-specific therapies. Stem cells and/or organ progenitors from normal or diseased tissue are mixed with Corning? Matrigel? matrix to create mini-organs of the: kidney, thyroid, liver, brain, lung, intestine, prostate, breast, esophagus, gastric, ovarian, and pancreas.

    Corning Matrigel matrix is the most published hydrogel for organoid research due to its close resemblance to an in vivo environment, providing necessary growth factors, proteins, and the required matrix architecture.

    Applications

    Matrigel Matrix for Organoids in Action

    Culture of Mouse Intestinal Organoids

    Culture of Mouse Intestinal Organoids

    See how the optimized Matrigel matrix for organoids supported the culture of mouse intestinal organoids.

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    3D Airway Organoids

    3D Airway Organoids

    Discover researcher’s high throughput gene expression analysis of 3D airway organoids.

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    Solutions Applied

    Corning Customers Unlock Scientific Possibilities with 3D

    Cell image

    Using Patient-derived Pancreatic Organoids Deliver Personalized Treatment

    Using Patient-derived Pancreatic Organoids Deliver Personalized Treatment

    Dr. Hervé Tiriac, from University of California (UC), San Diego, discusses the creation of a pancreatic organoid library to rest patient reactions to potential cancer therapies.

    Dr. Hervé Tiriac, from University of California (UC), San Diego, discusses the creation of a pancreatic organoid library to rest patient reactions to potential cancer therapies.

    Modeling Kidney Disease with Bioengineered Kidney Organoids

    Modeling Kidney Disease with Bioengineered Kidney Organoids

    Kidney organoid pioneer, Dr. Benjamin Freedman, explains the bioengineering, generation and application of 3D cell culture in studying kidney disease.

    Kidney organoid pioneer, Dr. Benjamin Freedman, explains the bioengineering, generation and application of 3D cell culture in studying kidney disease.

    3D Human “Mini Brains” to Improve Glioblastoma Treatment

    3D Human “Mini Brains” to Improve Glioblastoma Treatment

    Read more on the work of Dr. Amanda Linkous, who is working with ex vivo models of glioblastomas using human-derived stem cells to mimic the microenvironment of the human brain in vivo, in hopes to enable more effective treatment.

    Read more on the work of Dr. Amanda Linkous, who is working with ex vivo models of glioblastomas using human-derived stem cells to mimic the microenvironment of the human brain in vivo, in hopes to enable more effective treatment.

    How to Buy

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